文献信息
为什么放进合成菌群专题
整合 meta-omics、建模、互作网络和生物安全，把复杂微生物组转化为可干预系统。
核心解读
要点 1
meta-omics 和模型能帮助从相关性走向可干预控制点。
要点 2
空间、时间和环境尺度共同决定微生物组功能，不能只看组成表。
要点 3
生物安全和部署边界应纳入工程微生物组设计早期。
和专题导读的连接
- 概念层：帮助区分“多个菌一起培养”和“成员/功能/互作可定义的合成菌群”。
- 方法层：为成员选择、代谢分工、交叉喂养、群体控制或 DBTL 迭代提供一个切入点。
- 应用层：可作为后续判断生物制造、农业、环境修复或宿主系统文章是否值得深入解读的参考框架。
摘要级内容摘记
Microbiomes are complex and ubiquitous networks of microorganisms whose seemingly limitless chemical transformations could be harnessed to benefit agriculture, medicine, and biotechnology. The spatial and temporal changes in microbiome composition and function are influenced by a multitude of molecular and ecological factors. This complexity yields both versatility and challenges in designing synthetic microbiomes and perturbing natural microbiomes in controlled, predictable ways. In this review, we describe factors that give rise to emergent spatial and temporal microbiome properties and the meta-omics and computational modeling tools that can be used to understand microbiomes at the cellular and system levels. We also describe strategies for designing and engineering microbiomes to enhance or build novel functions. Throughout the review, we discuss key knowledge and technology gaps for elucidating the networks and deciphering key control points for microbiome engineering, and highlight examples where multiple omics and modeling approaches can be integrated to address these gaps.